Pharmacotherapy is the cornerstone treatment for patients with heart failure (HF) Baby that uses drugs targeting the renin-angiotensin-aldosterone system (RAAS), including angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan.This article r
Cutters A decisive element in the human cation channel TRPM2 is a region in its cytosolic C-terminus named NUDT9H because of its homology to the NUDT9 enzyme, a pyrophosphatase degrading ADP-ribose (ADPR).In hTRPM2, however, the NUDT9H domain has lost its enzymatic activity but serves as a binding domain for ADPR.As consequence of binding, gating o
This Waterers article aims to provide a guide that will help healthcare professionals and clinical researchers from all fields that deal with Kaplan-Meier curves.Survival analysis methods are among the most frequently used in the medical sciences and in clinical research.Overall survival, progression free survival, time to recurrence, or any other